Amyloidosis is a rare and serious illness, caused by extra-cellular accumulation of amyloid substance. The amyloid is created through misfolding of different proteins, which then become agent or “building blocks” for the amyloid, and the agent determines the sub-classification of the amyloidosis. This means that there are several causes of amyloidosis. The etiology spans from hereditary, relatively early onset forms, via clonal plasma cell illnesses to secondary types, which can be caused by chronic kidney failure, chronic inflammatory illnesses or chronic infections, to senile types. Similarly, symptomology and clinical presentation can vary widely and depend on the severity and spread to involved organs. The primary contact with the health sector can therefore be via many different specialties. Treatment of amyloidosis will vary greatly, depending on the triggering cause. Therefore, exact diagnosis is essential. Furthermore, early awareness of the diagnosis and early diagnosis are of the utmost importance for the prognosis.