Classification

Amyloidosis is classified according to the amyloigenic protein and according to whether the illness is hereditary or acquired, and whether the illness is localized or systemic.

The most frequent type of systemic amyloidosis in Denmark is AL amyloidosis.

AL amyloidosis (Amyloid Light) is caused by accumulation of misfolded light free kappa or lambda chains. Acquired illness with clonal plasma cells in the bone marrow. This type of light-chain amyloidosis can also be seen in connection with other clonal B-cell illnesses, including myeloma and lymphoma.

ATTR amyloidosis (Amyloid Transthyretin) is caused by accumulation of transthyretin and exists in an acquired, senile form, and in a rarer hereditary form.

AA amyloidose (Apoprotein A), also traditionally known as secondary amyloidosis. Classic causes are chronic infections and chronic inflammatory illnesses, e.g. rheumatoid arthritis. The occurrence is decreasing, following improved treatment of infections and rheumatism.

Beta-2-microglobulin amyloidosis, often secondary to chronic, severe kidney failure with a different cause.

Other, very rare, hereditary forms.